Rapid Test for Fecal Calprotectin Levels in Children With Crohn Disease

被引：37

作者：

Kolho, K. L. ^{[1
]}

Turner, D. ^{[2
]}

Veereman-Wauters, G. ^{[3
]}

Sladek, M. ^{[4
]}

de Ridder, L. ^{[5
]}

Shaoul, R. ^{[6
]}

Paerregaard, A. ^{[7
]}

Dias, J. Amil ^{[16
]}

Koletzko, S. ^{[8
]}

Nuti, F. ^{[9
]}

Bujanover, Y. ^{[10
]}

Staiano, A. ^{[11
]}

Bochenek, K. ^{[12
]}

Finnby, L. ^{[13
]}

Levine, A. ^{[14
]}

Veres, G. ^{[15
]}

机构：

[1] Univ Helsinki, Childrens Hosp, Helsinki Univ Cent Hosp, FIN-00029 Helsinki, Finland

[2] Hebrew Univ Jerusalem, Shaare Zedek Med Ctr, Pediat Gastroenterol Unit, IL-91905 Jerusalem, Israel

[3] Univ Hosp UZ Brussels, Pediat Gastroenterol Unit, Brussels, Belgium

[4] Jagiellonian Univ, Sch Med, Polish Amer Childrens Hosp, Krakow, Poland

[5] Erasmus MC Sophia Childrens Hosp, Pediat Gastroenterol Unit, Rotterdam, Netherlands

[6] Meyer Childrens Hosp, Rambam Med Ctr, Haifa, Israel

[7] Univ Copenhagen, Hvidovre Hosp, Dept Pediat, DK-2650 Hvidovre, Denmark

[8] Univ Munich, Dr von Haunersches Kinderspital, Munich, Germany

[9] Univ Roma La Sapienza, Dept Pediat, Rome, Italy

[10] Tel Aviv Univ, Sheba Med Ctr, Edmon & Lili Safra Childrens Hosp, IL-69978 Tel Aviv, Israel

[11] Univ Naples Federico II, Dept Pediat, Naples, Italy

[12] Med Univ Warsaw, Dept Pediat Gastroenterol & Nutr, Warsaw, Poland

[13] Lovisenberg Diakonale Hosp, Unger Vetlesens Inst, Oslo, Norway

[14] Tel Aviv Univ, Sackler Sch Med, Wolfson Med Ctr, Pediat Gastroenterol Unit, IL-69978 Tel Aviv, Israel

[15] Semmelweis Univ, Dept Pediat 1, H-1085 Budapest, Hungary

[16] Hosp Porto, Dept Pediat, Oporto, Portugal

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2012年 / 55卷 / 04期

关键词：

fecal biomarkers; inflammatory bowel disease; pediatric; INFLAMMATORY-BOWEL-DISEASE; GRANULOCYTE MARKER PROTEIN; ULCERATIVE-COLITIS; ACTIVITY INDEX; LACTOFERRIN; THERAPY; INFLIXIMAB;

D O I：

10.1097/MPG.0b013e318253cff1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100 mu g/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.

引用

页码：436 / 439

页数：4

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