Calcium-Catalyzed Dynamic Multicomponent Reaction

被引：22
|
作者：
Gao, Shuang [1 ]
Stopka, Tobias [1 ]
Niggemann, Meike [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 20期
关键词：
CHEMISTRY; HETEROCYCLES; SOLVOLYSIS;
D O I：
10.1021/acs.orglett.5b02593
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reversible formation of covalent bonds enabled by the remarkably high Lewis acidity of our calcium-based catalyst system was used for the development of a new type of multicomponent reaction. Accordingly, a pharmacologically interesting bicyclic amine was amplified from a highly efficient dynamic equilibrium. The product is formed with full diastereoselectivity, and as typical for our calcium-catalyzed reactions, precautions for the exclusion of air and moisture are unnecessary.
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页码：5080 / 5083
页数：4
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