An intramolecular [2+3] cycloaddition route to fused 5-heterosubstituted tetrazoles

被引：284
|
作者：
Demko, ZP
Sharpless, KB
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 25期
关键词：
D O I：
10.1021/ol010220x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Fused 5-heterotetrazole ring systems are synthesized in high yield via intramolecular [2 + 3] cycloadditions of organic azides and heteroatom-substituted nitriles. Cyanates, thiocyanates, and cyanamides are all competent dipolarophiles for this reaction. A variety of scaffolds are tolerated when the new enclosed ring is five- or six-membered.
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收藏
页码：4091 / 4094
页数：4
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