Synthesis of polysubstituted fused pyrrolidines via [2+2]/[2+3] cycloaddition of azomethine ylides

被引：0
|
作者：
Ou, Chunyan [1 ]
Wang, Jian [1 ]
Yin, Pingping [1 ]
Chen, Bin [1 ]
Hu, Ping [1 ]
Wang, Bi-Qin [1 ]
Cao, Peng [1 ]
Xu, Minghui [1 ]
机构：
[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 15期
关键词：
1,3-DIPOLAR CYCLOADDITION; ELECTRONIC-STRUCTURE; BUILDING-BLOCKS; C-C; INHIBITOR; NITROGEN; ALKENES; CYCLOBUTENONES; INTERMEDIATE; CONSTRUCTION;
D O I：
10.1039/d4qo00483c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general approach to dense substitution patterns via [2 + 2]/[2 + 3] cycloaddition between nonstabilized azomethine ylides, alkynes and silyl enol ethers is elaborated. This approach not only allowed the preparation of novel molecules, but also significantly simplified the synthesis of the existing ones. 3-Azabicyclo[3.2.0]heptanes which contain polysubstituted cyclobutanes could be obtained in medium to good yields with excellent diastereoselectivities.
引用
收藏
页码：4149 / 4155
页数：7
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