Effect of Composite Alumina and Carbon Nanotubes on Cell Viability In Vitro

被引：0

作者：

Restrepo, N. ^{[1
]}

Lopera, A. M. ^{[1
]}

Claudia, G. ^{[2
]}

Villegas, P. ^{[1
]}

Arroyave, J. C. ^{[1
]}

机构：

[1] Inst Tecnol Metropolitano, Grp Invest & Innovac Biomed GI2B, Medellin, Colombia

[2] Univ Nacl Colombia, Grp Mat Ceram & Vitreos, Sede Medellin, Colombia

来源：

VI LATIN AMERICAN CONGRESS ON BIOMEDICAL ENGINEERING (CLAIB 2014) | 2014年 / 49卷

关键词：

alumina ceramic; carbon nanotubes; composite materials; cell viability; biocompatibility; BIOCOMPATIBILITY;

D O I：

10.1007/978-3-319-13117-7_41

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Alumina ceramic is a biocompatible material with high potential in bone implant applications. Due to this material lacks enough mechanical properties for this purpose, it is necessary to develop new composites of alumina matrix for bone tissue regeneration. In this paper, the effect of carbon nanotubes/alumina on cell viability in vitro was evaluated. Methodology: Vero cells were treated with 125-5000 pg/ml of alumina composite. After 72h, Hoechst staining and MTT assay (3 (4, 5 dimethyl-2-thiazoyl) -2, 5-diphenyltetrazolic)) were performed for measuring cell viability. Results and Conclusions: The alumina ceramic composite with carbon nanotubes did not significatively affect cell viability with low percentages of carbon nanotubes (0,5 and 1,0%) but a cytotoxic effect was observed with high doses of carbon nanotubes (1,5%). Biocompatibility properties of alumina ceramic composite with carbon nanotubes must be further explored in different in vitro cell models.

引用

页码：155 / 158

页数：4

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