At present in Mexico, the renewable energy has become more important due to the great dependence of the country for fossil fuels. Within the several applications of renewable energy, there are the geothermal applications for the air conditioning of spaces. This technology employs heat pumps that interexchange heat with the ground. This technology is relatively young in Mexico, leaving a large field for study and application throughout the country. In this way, to calculate the correct sizing of geothermal heat exchangers, it is necessary to calculate the thermal loads of the complex in which this technology of geothermal heat pumps using vertical heat exchangers type U will be installed, to perform the calculation of thermal loads Autodesk Revit (R) software was used, with which was possible to make a virtual model in detail of the botanical center that is located in Morelia, Michoacan, Mexico and belongs to the Universidad Michoacana de San Nicolas de Hidalgo (UMNSH). This study shows the results of the analysis of the installations and determination of the thermal loads of the complex due to this type of infrastructure. By obtaining the values of the thermal loads, the dimensioning of the heat exchanger was archived, which will have to be installed to cover the thermal requirement of this system and his installation, in addition to the selection of the heat pump. This complex of 2 levels, where, on the first floor there are cubicles and laboratories and on the second floor, several common areas. The design was developed in detail; doors, windows, aluminum works, which will be taken into account for solar incidence heat gains, heat conduction through walls, ceilings and losses on the ground. There were also introduced in detail the miscellaneous equipment that will be operating within the complex and provide heat in their operation such as: computers, printers, coffee machines etc., another factor of great caloric intake, is the lighting that was also included in the calculation, as it is presented in the building. After obtaining the thermal loads, the GLHEPro software was used for dimensioning the Vertical heat exchangers with the number and depth of the exchangers was obtained. the GLD 2014 software was used for dimensioning the Horizontal heat exchangers with the number and depth of the exchangers was obtained.