Oncometabolite-Independent Anti-Apoptotic Feature Via Phospholipid Metabolic Adaptation in IDH2 Mutant AML Cells

被引：0
|
作者：
Morishima, Tatsuya [1 ,2 ]
Takahashi, Koichi [3 ,4 ]
Chin, Desmond Wai Loon [5 ]
Tokunaga, Kenji [6 ]
Arima, Yuichiro [7 ]
Matsuoka, Masao [6 ]
Suda, Toshio [5 ,8 ]
Takizawa, Hitoshi [2 ]
机构：
[1] Kumamoto Univ, Int Res Ctr Med Sci, Lab Hematopoiet Stem Cell Engn, Kumamoto, Japan
[2] Kumamoto Univ, Int Res Ctr Med Sci, Lab Stem Cell Stress, Kumamoto, Japan
[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX USA
[5] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore
[6] Kumamoto Univ Hosp, Dept Hematol Rheumatol & Infect Dis, Kumamoto, Japan
[7] Kumamoto Univ, Int Res Ctr Med Sci, Lab Dev Cardiol, Kumamoto, Japan
[8] Kumamoto Univ, Int Res Ctr Med Sci, Lab Stem Cell Regulat, Kumamoto, Japan
来源：
BLOOD | 2022年 / 140卷
关键词：
D O I：
10.1182/blood-2022-162976
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：3012 / 3013
页数：2
相关论文
共 34 条
  • [1] Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells
    Morishima, Tatsuya
    Takahashi, Koichi
    Chin, Desmond Wai Loon
    Wang, Yuxin
    Tokunaga, Kenji
    Arima, Yuichiro
    Matsuoka, Masao
    Suda, Toshio
    Takizawa, Hitoshi
    CANCER SCIENCE, 2024, 115 (01) : 197 - 210
  • [2] IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML
    Thomas, Daniel
    Nakauchi, Yusuke
    Wu, Manhong
    Zheng, Ming
    Sinha, Subarna
    Dill, David
    Peltz, Gary
    Majeti, Ravindra
    BLOOD, 2018, 132
  • [3] Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
    Chen, Dong
    Xia, Siyuan
    Zhang, Rukang
    Li, Yuancheng
    Famulare, Christopher A.
    Fan, Hao
    Wu, Rong
    Wang, Mei
    Zhu, Allen C.
    Elf, Shannon E.
    Su, Rui
    Dong, Lei
    Arellano, Martha
    Blum, William G.
    Mao, Hui
    Lonial, Sagar
    Stock, Wendy
    Odenike, Olatoyosi
    Le Beau, Michelle
    Boggon, Titus J.
    He, Chuan
    Chen, Jianjun
    Gao, Xue
    Levine, Ross L.
    Chen, Jing
    MOLECULAR CELL, 2021, 81 (18) : 3833 - +
  • [4] AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo
    Shih, Alan H.
    Shank, Kaitlyn R.
    Meydan, Cem
    Intlekofer, Andrew M.
    Ward, Patrick
    Thompson, Craig B.
    Melnick, Ari M.
    Travins, Jeremy
    Straley, Kim
    Gliser, Camelia
    Yen, Katherine
    Levine, Ross L.
    BLOOD, 2014, 124 (21)
  • [5] Defective pathogen recognition and anti-apoptotic pathways in dendritic cells from NOD2 mutant Crohn's disease patients
    Zelinkova, Z.
    van Beelen, A. J.
    de Kort, F.
    Moerland, P. D.
    vanThemaat, P. E. Verloren
    Velde, A. A. te
    van Deventer, S. J.
    de Jong, E. C.
    Hommes, D. W.
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2007, 19 (10) : A80 - A80
  • [6] Thermobiochemical evidence for the rapid metabolic rate in hybridoma cells genetically engineered to overexpress the anti-apoptotic protein bcl-2 in batch culture
    Feng, Y
    Olomolaiye, D
    Kemp, RB
    THERMOCHIMICA ACTA, 2004, 417 (02) : 207 - 216
  • [7] Adaptation of HepG2 cells to silver nanoparticles-induced stress is based on the pro-proliferative and anti-apoptotic changes in gene expression
    Brzoska, Kamil
    Meczynska-Wielgosz, Sylwia
    Stepkowski, Tomasz M.
    Kruszewski, Marcin
    MUTAGENESIS, 2015, 30 (03) : 431 - 439
  • [8] Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo
    Jason J. Zoeller
    Roderick T. Bronson
    Laura M. Selfors
    Gordon B. Mills
    Joan S. Brugge
    npj Breast Cancer, 3
  • [9] Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo
    Zoeller, Jason J.
    Bronson, Roderick T.
    Selfors, Laura M.
    Mills, Gordon B.
    Brugge, Joan S.
    NPJ BREAST CANCER, 2017, 3
  • [10] 50% Ethanolic Extract of Apple Polyphenols Protects Pancreatic β-cells from Damage by H2O2 via its Anti-apoptotic Effects
    Mao, Shanshan
    Song, Guangming
    Liu, Dailin
    Gao, Xiaoxia
    Zhao, Yanmin
    Li, Xiewen
    LATIN AMERICAN JOURNAL OF PHARMACY, 2015, 34 (01): : 177 - 182
1234