Antinociceptive effect of ten day administration of Ukrain in mice and interaction of the treatment with morphine

被引：0

作者：

JagielloWojtowicz, E ^{[1
]}

Kleinrok, Z ^{[1
]}

Chodkowska, A ^{[1
]}

Nowicky, JW ^{[1
]}

Piper, H ^{[1
]}

Kubiatowski, T ^{[1
]}

机构：

[1] UKRAINIAN ANTI CANC INST, A-1040 VIENNA, AUSTRIA

来源：

DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH | 1996年 / 22卷 / 3-5期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study shows that Ukrain, administered i.p. in doses of 9.5 and 19 mg/kg once daily for 10 days in mice, produced evident antinociceptive action in the writhing syndrome and hotplate tests. Moreover, we found that as a result of 10-day treatment with Ukrain the antinociceptive action of morphine (0.1 mg/kg s.c. administered after the last dose of Ukrain) was significantly decreased. These results and the observed interaction between Ukrain and morphine seem to be contraindications to their combined usage.

引用

页码：201 / 203

页数：3

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