Failure of rearranged TCR transgenes to prevent age-associated thymic involution

被引:0
|
作者
Lacorazza, HD
Guevara-Patiño, JA
Weksler, ME
Radu, D
Nikolic-Zugic, J
机构
[1] Mem Sloan Kettering Canc Ctr, Lab T Cell Dev, Program Immunol, New York, NY 10021 USA
[2] Weill Med Coll, Div Geriatr & Gerontol, New York, NY 10021 USA
[3] Cornell Univ, Weill Grad Sch Med Sci, New York, NY 10021 USA
[4] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10129 USA
来源
JOURNAL OF IMMUNOLOGY | 1999年 / 163卷 / 08期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
After puberty, the thymus undergoes a dramatic loss in volume, in weight and in the number of thymocytes, a phenomenon termed age-associated thymic involution, Recently, it was reported that age-associated thymic involution did not occur in mice expressing a rearranged transgenic (Tg) TCR alpha beta receptor. This finding implied that an age-associated defect in TCR rearrangement was the major, if not the only, cause for thymic involution. Here, we examined thymic involution in three other widely used MHC class I-restricted TCR alpha beta Tg mouse strains and compared it with that in non-Tg mice. In all three TCR alpha beta Tg strains, as in control mice, thymocyte numbers were reduced by similar to 90% between 2 and 24 mo of age. The presence or absence of the selecting MHC molecules did not alter this age-associated cell loss, Our results indicate that the expression of a rearranged TCR alone cannot, by itself prevent thymic involution, Consequently, other presently unknown factors must also contribute to this phenomenon.
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页码:4262 / 4268
页数:7
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