Apelin drives endothelial cell migration toward intestinal progenitor cells

被引：0
|
作者：
Bernier-Latmani, Jeremiah [1 ]
Petrova, Tatiana V. [1 ]
机构：
[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne, Switzerland
来源：
NATURE CARDIOVASCULAR RESEARCH | 2022年 / 1卷 / 06期
关键词：
D O I：
10.1038/s44161-022-00079-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Elucidation of the mechanisms that drive tumor resistance to anti-angiogenic therapies is expected to improve treatment options. This report shows that endothelial apelin signaling promotes the migration of distant venous endothelial cells toward the tumor progenitor cell niche to support vessel expansion and sustain a normoxic microenvironment, and that it does so independently of vascular endothelial growth factor A.
引用
收藏
页码：546 / 547
页数：2
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