Synthesis of the ester side chains of homoharringtonine and harringtonine using lactones as building blocks

被引：3

作者：

Dang, Fang-Fang ^{[1
]}

Wang, Cui-Cui ^{[2
]}

Han, Feng ^{[3
]}

Zhang, Zhi-Wei ^{[2
]}

机构：

[1] Xian Univ Architecture & Technol, Sch Chem & Chem Engn, Xian, Peoples R China

[2] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, Yuxiang Rd 26, Shijiazhuang 050018, Hebei, Peoples R China

[3] CSPC Innovat Pharmaceut Co Ltd, Shijiazhuang, Hebei, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 02期

关键词：

Alkaloid; classic reactions; efficient synthesis; ester side chain; homoharringtonine; ENANTIOSELECTIVE SYNTHESIS; REARRANGEMENT; ALKALOIDS;

D O I：

10.1080/00397911.2020.1829643

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient synthesis of the ester side chains of homoharringtonine and harringtonine using lactones as building blocks has been developed. The synthesis used classic reactions from readily available starting materials. Reactions of the lactone bearing an oxo-containing alpha-tetrasubstituted center with MeOH and cephalotaxine, respectively, proceeded smoothly to give the corresponding ring-opening products in 80% and 65% yield.

引用

页码：317 / 323

页数：7

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