Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells

被引：32
|
作者：
Wang, Ying [1 ,2 ]
Zhang, Dongmei [1 ,2 ]
Ye, Wencai [1 ,2 ]
Yin, Zhiqi [3 ]
Fung, Kwok-Pui [4 ,5 ]
Zhao, Shouxue [3 ]
Yao, Xinsheng [1 ,2 ]
机构：
[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China
[3] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China
[4] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
来源：
PLANTA MEDICA | 2008年 / 74卷 / 10期
关键词：
Androsace umbellato; primulaceae; triterpenoid saponin; antiproliferative activity; human hepatoma cells;
D O I：
10.1055/s-2008-1081291
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new triterpenoid saponins, along with five known ones, were isolated from the EtOH extract of the whole plants of Androsace umbellata. The structures of the new triterpenoid saponins were identified as 3-O-{beta-D-Xylopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-[beta-D-glucopyranosyl-(1 -> 2)1-alpha-L-arabinopyranosyl}-3 beta-hydroxy-(13 beta,28-epoxy-16-oxo-oleanan-30-al (1) and 3-O-beta-D-Xylopyranosyl-(1 -> 2)-beta-D-glucopyranosyl(1 -> 4)-alpha-L-arabinopyranosyl-3 beta-hydroxy-13 beta,28-epoxy- 16-oxo-oleanan-30-al (2) on the basis of their spectral and chemical properties. All these compounds showed significant cytotoxic activities in human hepatoma cells.
引用
收藏
页码：1280 / 1284
页数：5
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