Discovery of pentacyclic triterpenoid glycosides with anti-proliferative activities from Ardisia lindleyana

被引：1

作者：

Wei, Zhen-Zhen ^{[1
,2
]}

Zhou, Ti-Qiang ^{[3
]}

Zhang, Jing-Rui ^{[2
,4
]}

Xia, Zi-Ming ^{[2
]}

Liu, Si-Fan ^{[2
]}

Liu, Chun-Ying ^{[2
,4
]}

Li, Min ^{[2
]}

Zhang, Guang-Jie ^{[2
]}

Tian, Ying ^{[2
]}

Li, Bin ^{[2
]}

Wang, Lin ^{[1
,2
]}

Liu, Shu-Chen ^{[2
]}

机构：

[1] Beijing Univ Technol, Fac Environm & Life, Beijing 100022, Peoples R China

[2] Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China

[3] Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Inst Engn Med, Sch Life Sci,Key Lab Mol Med & Biotherapy,Key Lab, Beijing 100081, Peoples R China

[4] Henan Univ, Sch Pharm, Kaifeng 475001, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2023年 / 524卷

关键词：

Ardisia lindleyana; Glycoside; Triterpenoid; Anti-proliferative activity; Apoptosis; SAPONINS;

D O I：

10.1016/j.carres.2023.108761

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One new pentacyclic triterpenoid glycoside, ardisiapunine E (1), along with two known compounds were isolated from the root of Ardisia lindleyana D.Dietr. Their structures were elucidated by 1H and 13C NMR, DEPT, HMBC, HSQC, 1H-1H COSY and NOESY spectroscopic analyses, ESI-MS, and literature. Compounds 1-3 exhibited obvious anti-proliferative activities against the HeLa cell line in a dose-and time-dependent manner by inducing G2/M phase arrest and apoptosis in vitro, both consisting of pentacyclic triterpenes and sugar. Hence, this study identified a new and two known pentacyclic triterpenoid glycosides promoting apoptosis as a potential anti -proliferative agent.

引用

页数：7

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