Palladium(III)-Catalyzed Fluorination of Arylboronic Acid Derivatives

被引：125

作者：

Mazzotti, Anthony R. ^{[1
]}

Campbell, Michael G. ^{[1
]}

Tang, Pingping ^{[1
]}

Murphy, Jennifer M. ^{[1
]}

Ritter, Tobias ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 38期

基金：

美国国家科学基金会;

关键词：

COPPER-MEDIATED FLUORINATION; C-H FLUORINATION; REDUCTIVE ELIMINATION; ELECTROPHILIC FLUORINATION; PD(III); DEOXYFLUORINATION; CONVERSION; MECHANISM;

D O I：

10.1021/ja405919z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.

引用

页码：14012 / 14015

页数：4

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