Roles of the Translation Initiation Factor eIF2α Phosphorylation in Cell Structure and Function

被引：9
|
作者：
Back, Sung Hoon [1 ]
机构：
[1] Univ Ulsan, Sch Biol Sci, Ulsan 44610, South Korea
来源：
CELL STRUCTURE AND FUNCTION | 2020年 / 45卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
eIF2 alpha phosphorylation; Translation; Unfolded Protein Response; Reactive Oxygen Species; Mitochondria; UNFOLDED PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM STRESS; MESSENGER-RNA TRANSLATION; OPEN READING FRAMES; ELF2-ALPHA PHOSPHORYLATION; LINKS MITOCHONDRIAL; OXIDATIVE STRESS; GENE-EXPRESSION; KEY REGULATOR; ER-STRESS;
D O I：
10.1247/csf.20013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It is often assumed that alpha-subunit phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) complex is just a mechanism to control protein synthesis. However, eIF2 alpha phosphorylation induced by multiple kinases can recognize various intracellular and extracellular stress conditions, and it is involved in various other cellular processes beyond protein synthesis. This review introduces the roles of eIF2 alpha phosphorylation in translational regulation, the generation of reactive oxygen species, changes in mitochondria structure and shape, and mitochondrial retrograde signaling pathways in response to diverse stress conditions.
引用
收藏
页码：65 / 76
页数：12
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