Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review

被引：9
|
作者：
Siepe, Giambattista [1 ]
Buwenge, Milly [1 ]
Nguyen, Nam P. [2 ]
Macchia, Gabriella [3 ]
Deodato, Francesco [3 ]
Cilla, Savino [4 ]
Mattiucci, Gian C. [5 ]
Capocaccia, Ilaria [1 ]
Cammelli, Silvia [1 ]
Guido, Alessandra [1 ]
Arcelli, Alessandra [1 ]
Ntreta, Maria [1 ]
Guerri, Sara [6 ]
Morganti, Alessio G. [1 ]
机构：
[1] Univ Bologna, S Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med DIMES, Radiat Oncol Ctr, Via Massarenti 9, I-40138 Bologna, Italy
[2] Howard Univ, Coll Med, Dept Radiat Oncol, Washington, DC USA
[3] Univ Cattolica Sacro Cuore, Radiotherapy Unit, Fdn Giovanni Paolo 2, Campobasso, Italy
[4] Univ Cattolica Sacro Cuore, Med Phys Unit, Fdn Giovanni Paolo 2, Campobasso, Italy
[5] Univ Cattolica Sacro Cuore, Dept Radiat Oncol, Rome, Italy
[6] Univ Bologna, Div Radiol, S Orsola Malpighi Hosp, Dept Expt & Specialty Med DIMES, Bologna, Italy
来源：
ANTICANCER RESEARCH | 2018年 / 38卷 / 03期
关键词：
Hypofractionation; postoperative; prostate cancer; radiotherapy; review; INTENSITY-MODULATED RADIOTHERAPY; SIMULTANEOUS INTEGRATED BOOST; RADICAL PROSTATECTOMY; ADJUVANT RADIOTHERAPY; SALVAGE RADIOTHERAPY; ACUTE TOXICITY; HELICAL TOMOTHERAPY; PHASE I/II; CANCER; TRIAL;
D O I：
10.21873/anticanres.12343
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: A systematic review on toxicity, local control (LC), overall survival (OS), and biochemical relapse-free survival (bRFS) after postoperative hypofractionated radiotherapy (HFRT) on prostate cancer (PCa) was performed. Materials and Methods: Based on the PRISMA methodology, studies reporting clinical results after adjuvant or salvage HFRT were included. Results: A total of 1,208 patients from 17 eligible studies were included. Median follow-up was 30 months. No case of severe acute gastrointestinal (GI) toxicity was recorded. Grade >= 3 acute genitourinary (GU) toxicity ranged between 0% and 3%. Different rates of grade >= 2 late GI (range= 0-8.7%) and GU (range=0-66%) toxicity were recorded. Encouraging results on LC, OS, and bRFS were reported. Conclusion: Acute toxicity does not seem to be increased in patients receiving postoperative HFRT, but the results of late-GU toxicity are conflicting. Further prospective studies are needed before including postoperative HFRT in clinical practice.
引用
收藏
页码：1221 / 1230
页数：10
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