Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review

被引：9

作者：

Siepe, Giambattista ^{[1
]}

Buwenge, Milly ^{[1
]}

Nguyen, Nam P. ^{[2
]}

Macchia, Gabriella ^{[3
]}

Deodato, Francesco ^{[3
]}

Cilla, Savino ^{[4
]}

Mattiucci, Gian C. ^{[5
]}

Capocaccia, Ilaria ^{[1
]}

Cammelli, Silvia ^{[1
]}

Guido, Alessandra ^{[1
]}

Arcelli, Alessandra ^{[1
]}

Ntreta, Maria ^{[1
]}

Guerri, Sara ^{[6
]}

Morganti, Alessio G. ^{[1
]}

机构：

[1] Univ Bologna, S Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med DIMES, Radiat Oncol Ctr, Via Massarenti 9, I-40138 Bologna, Italy

[2] Howard Univ, Coll Med, Dept Radiat Oncol, Washington, DC USA

[3] Univ Cattolica Sacro Cuore, Radiotherapy Unit, Fdn Giovanni Paolo 2, Campobasso, Italy

[4] Univ Cattolica Sacro Cuore, Med Phys Unit, Fdn Giovanni Paolo 2, Campobasso, Italy

[5] Univ Cattolica Sacro Cuore, Dept Radiat Oncol, Rome, Italy

[6] Univ Bologna, Div Radiol, S Orsola Malpighi Hosp, Dept Expt & Specialty Med DIMES, Bologna, Italy

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 03期

关键词：

Hypofractionation; postoperative; prostate cancer; radiotherapy; review; INTENSITY-MODULATED RADIOTHERAPY; SIMULTANEOUS INTEGRATED BOOST; RADICAL PROSTATECTOMY; ADJUVANT RADIOTHERAPY; SALVAGE RADIOTHERAPY; ACUTE TOXICITY; HELICAL TOMOTHERAPY; PHASE I/II; CANCER; TRIAL;

D O I：

10.21873/anticanres.12343

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: A systematic review on toxicity, local control (LC), overall survival (OS), and biochemical relapse-free survival (bRFS) after postoperative hypofractionated radiotherapy (HFRT) on prostate cancer (PCa) was performed. Materials and Methods: Based on the PRISMA methodology, studies reporting clinical results after adjuvant or salvage HFRT were included. Results: A total of 1,208 patients from 17 eligible studies were included. Median follow-up was 30 months. No case of severe acute gastrointestinal (GI) toxicity was recorded. Grade >= 3 acute genitourinary (GU) toxicity ranged between 0% and 3%. Different rates of grade >= 2 late GI (range= 0-8.7%) and GU (range=0-66%) toxicity were recorded. Encouraging results on LC, OS, and bRFS were reported. Conclusion: Acute toxicity does not seem to be increased in patients receiving postoperative HFRT, but the results of late-GU toxicity are conflicting. Further prospective studies are needed before including postoperative HFRT in clinical practice.

引用

页码：1221 / 1230

页数：10

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