A Review of Photodynamic Therapy for Neoplasms of the Head and Neck

被引：73

作者：

Civantos, Francisco J. ^{[1
]}

Karakullukcu, Baris ^{[2
]}

Biel, Merrill ^{[3
,4
]}

Silver, Carl E. ^{[5
]}

Rinaldo, Alessandra ^{[6
]}

Saba, Nabil F. ^{[7
]}

Takes, Robert P. ^{[8
]}

Vander Poorten, Vincent ^{[9
,10
]}

Ferlito, Alfio ^{[11
]}

机构：

[1] Univ Miami, Dept Otolaryngol Head & Neck Surg, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[2] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Amsterdam, Netherlands

[3] Univ Minnesota, Minneapolis, MN USA

[4] Ear Nose & Throat Specialty Care Minnesota, Minneapolis, MN USA

[5] Univ Arizona, Coll Med Phoenix, Dept Surg, Phoenix, AZ USA

[6] Univ Udine, Sch Med, Udine, Italy

[7] Emory Univ, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA

[8] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, Nijmegen, Netherlands

[9] Katholieke Univ Leuven, Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[10] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Oncol, Sect Head & Neck Oncol, Leuven, Belgium

[11] Int Head & Neck Sci Grp, Padua, Italy

来源：

ADVANCES IN THERAPY | 2018年 / 35卷 / 03期

关键词：

Head and neck cancer; Laryngeal cancer; Lip cancer; Nasopharyngeal cancer; Oral cavity cancer; Oropharyngeal cancer; Oncology; Photodynamic therapy; Squamous cell carcinoma; SQUAMOUS-CELL CARCINOMA; NEAR-INFRARED PHOTOIMMUNOTHERAPY; STAGE ORAL-CAVITY; PHOTORADIATION THERAPY; MALIGNANT-TUMORS; NASOPHARYNGEAL CARCINOMA; SINGLET OXYGEN; INCURABLE HEAD; RECURRENT HEAD; IN-VIVO;

D O I：

10.1007/s12325-018-0659-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Photodynamic therapy (PDT) involves the use of a phototoxic drug which is activated by low powered laser light to destroy neoplastic cells. Multiple photosensitizers have been studied and tumors have been treated in a variety of head and neck sites over the last 30 years. PDT can effectively treat head and neck tumors, particularly those of the superficial spreading type, and the classic application of this technology has been in the patient with a wide field of dysplastic change and superficial carcinomatosis. Interstitial treatment has been used to treat more invasive cancer. Data is available from case series and institutional experiences, but very little randomized data is available. We review the mechanisms of action, historical development, available data, and current knowledge regarding PDT for the various head and neck subsites, and discuss possible future directions, with an emphasis on clinical application.

引用

页码：324 / 340

页数：17

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