In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review

被引：39

作者：

Sheshala, Ravi ^{[1
]}

Anuar, Nor Khaizan ^{[1
,2
]}

Abu Samah, Nor Hayati ^{[1
]}

Wong, Tin Wui ^{[2
]}

机构：

[1] Univ Teknol MARA Selangor, Dept Pharmaceut, Fac Pharm, Puncak Alam Campus, Bandar Puncak Alam 42300, Malaysia

[2] Univ Teknol MARA Selangor, Nondestruct Biomed & Pharmaceut Res Ctr, iPROMISE, Puncak Alam Campus, Bandar Puncak Alam 42300, Malaysia

来源：

AAPS PHARMSCITECH | 2019年 / 20卷 / 05期

关键词：

in vitro dissolution; in vitro permeation; nanocarrier; skin; topical; transdermal; SOLID LIPID NANOPARTICLES; DIFFERENTIAL-PULSE POLAROGRAPHY; LOADED CHITOSAN NANOPARTICLES; TRANSDERMAL DELIVERY; TOPICAL DELIVERY; VIVO CORRELATION; CHITIN NANOGEL; FIBER-OPTICS; RELEASE; PENETRATION;

D O I：

10.1208/s12249-019-1362-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro dissolution/permeation methods are available for skin product testing with no specific application to nanocarriers. Researchers are largely utilizing the in-house dissolution/permeation testing methods of nanocarriers. These drug release and permeation methods are pending to be standardized. Their biorelevance with reference to in vivo plasma concentration-time profiles requires further exploration to enable translation of in vitro data for in vivo or clinical performance prediction.

引用

页数：28

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