Role of αvβ3 integrin receptors in breast tumor

被引：0

作者：

Sengupta, S ^{[1
]}

Chattopadhyay, N ^{[1
]}

Mitra, A ^{[1
]}

Ray, S ^{[1
]}

Dasgupta, S ^{[1
]}

Chatterjee, A ^{[1
]}

机构：

[1] Chittaranjan Natl Canc Inst, Dept Receptor Biol & Tumour Metastasis, Kolkata 700026, W Bengal, India

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2001年 / 20卷 / 04期

关键词：

breast cancer; malignant; integrins; invasion;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The intriguing problem of tumor metastasis involves adhesion of the metastasic cells via the integrin group of cell surface receptors to the ECM proteins of the basement membrane. Modulation of integrin family of cell surface receptors is believed to be associated with stages of tumor metastasis. In this present study, results obtained indicate that alphavbeta3 vitronectin receptors may play an important role in the malignant behaviour of human breast tumor. alphavbeta3 integrin receptors can modulate the activity of collagenase enzyme and thereby the invasive property of breast tumor cells.

引用

页码：585 / 590

页数：6

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