Apicomplexan plastids as drug targets

被引：187
|
作者：
McFadden, GI [1 ]
Roos, DS
机构：
[1] Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Parkville, Vic 3052, Australia
[2] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
来源：
TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 08期
基金：
美国国家卫生研究院; 澳大利亚研究理事会;
关键词：
D O I：
10.1016/S0966-842X(99)01547-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Prokaryotic metabolic pathways in the relict plastid of apicomplexan parasites make this organelle a promising target for drug development. The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities.
引用
收藏
页码：328 / 333
页数：6
相关论文
共 50 条
  • [41] HIV drug targets
    Oirere, Shem
    CHEMISTRY & INDUSTRY, 2020, 84 (04) : 17 - 17
  • [42] GWAS and drug targets
    Chen Cao
    John Moult
    BMC Genomics, 15
  • [43] Ribonucleases as Drug Targets
    Canestrari, Emanuele
    Paroo, Zain
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (10) : 855 - 866
  • [44] Re-Envisioning Anti-Apicomplexan Parasite Drug Discovery Approaches
    Rangel, Gabriel W.
    Llinas, Manuel
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11
  • [45] COMPARATIVE CHEMICAL GENOMICS IN BABESIA SPECIES IDENTIFIES A NOVEL APICOMPLEXAN DRUG TARGET
    Keroack, Caroline D.
    Elsworth, Brendan
    Tennessen, Jacob A.
    Moreira, Cristina K.
    Paul, Aditya S.
    Duraisingh, Manoj T.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 101 : 620 - 621
  • [46] CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery
    H. J. Benns
    M. Storch
    J. A. Falco
    F. R. Fisher
    F. Tamaki
    E. Alves
    C. J. Wincott
    R. Milne
    N. Wiedemar
    G. Craven
    B. Baragaña
    S. Wyllie
    J. Baum
    G. S. Baldwin
    E. Weerapana
    E. W. Tate
    M. A. Child
    Nature Microbiology, 2022, 7 : 1891 - 1905
  • [47] CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery
    Benns, H. J.
    Storch, M.
    Falco, J. A.
    Fisher, F. R.
    Tamaki, F.
    Alves, E.
    Wincott, C. J.
    Milne, R.
    Wiedemar, N.
    Craven, G.
    Baragana, B.
    Wyllie, S.
    Baum, J.
    Baldwin, G. S.
    Weerapana, E.
    Tate, E. W.
    Child, M. A.
    NATURE MICROBIOLOGY, 2022, 7 (11) : 1891 - +
  • [48] PLASTIDS
    WELLBURN, AR
    INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1987, : 149 - 210
  • [49] Opinion - Drugs, their targets and the nature and number of drug targets
    Imming, Peter
    Sinning, Christian
    Meyer, Achim
    NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (10) : 821 - 834
  • [50] Erratum: Drugs, their targets and the nature and number of drug targets
    Peter Imming
    Christian Sinning
    Achim Meyer
    Nature Reviews Drug Discovery, 2007, 6 : 168 - 168
12345