Novel pH and temperature-sensitive block copolymers:: Poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(β-amino ester)

被引：23

作者：

Yoo, JS

Kim, MS

Lee, DS ^{[1
]}

Kim, BS

Kim, JH

机构：

[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea

[2] Sungkyunkwan Univ, Polymer Technol Inst, Suwon 440746, South Korea

[3] Sungkyunkwan Univ, Dept Chem Engn, Suwon 440746, South Korea

来源：

MACROMOLECULAR RESEARCH | 2006年 / 14卷 / 01期

关键词：

D O I：

10.1007/BF03219078

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel pH and temperature-sensitive MPEG-PCL-PAE triblock copolymers were synthesized by the ring-opening and Michael reaction. MPEG-PCL-PAE shows a sol-gel transition by ionization-deionization of PAE block. At low temperature and high pH, MPEG-PCL-PAE changed into a gel state by micelle packing. MPEG-PCL-PAE, showing a gel state at 37°C and pH 7.4, was synthesized. This polymer will be applicable to injectable hydrogel for DDS.

引用

页码：117 / 120

页数：4

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