Novel pH and temperature-sensitive block copolymers:: Poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(β-amino ester)

被引：23
|
作者：
Yoo, JS
Kim, MS
Lee, DS [1 ]
Kim, BS
Kim, JH
机构：
[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea
[2] Sungkyunkwan Univ, Polymer Technol Inst, Suwon 440746, South Korea
[3] Sungkyunkwan Univ, Dept Chem Engn, Suwon 440746, South Korea
来源：
MACROMOLECULAR RESEARCH | 2006年 / 14卷 / 01期
关键词：
D O I：
10.1007/BF03219078
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Novel pH and temperature-sensitive MPEG-PCL-PAE triblock copolymers were synthesized by the ring-opening and Michael reaction. MPEG-PCL-PAE shows a sol-gel transition by ionization-deionization of PAE block. At low temperature and high pH, MPEG-PCL-PAE changed into a gel state by micelle packing. MPEG-PCL-PAE, showing a gel state at 37°C and pH 7.4, was synthesized. This polymer will be applicable to injectable hydrogel for DDS.
引用
收藏
页码：117 / 120
页数：4
相关论文
共 50 条
  • [1] Novel pH and temperature-sensitive block copolymers: Poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(β-amino ester)
    Je Sun Yoo
    Min Sang Kim
    Doo Sung Lee
    Bong Sup Kim
    Ji Heung Kim
    [J]. Macromolecular Research, 2006, 14 : 117 - 120
  • [2] Synthesis and crystallizability of poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(ethylene glycol)
    Wang, Pei
    Liu, Lian
    Qu, Chao
    Wei, Zhiyong
    Qi, Min
    [J]. JOURNAL OF CONTROLLED RELEASE, 2011, 152 : E240 - E242
  • [3] Synthesis and Characterization of Poly(ε-caprolactone)-b-Poly(ethylene glycol)-b-Poly(ε-caprolactone) Triblock Copolymers with Dibutylmagnesium as Catalyst
    Wei, Zhiyong
    Liu, Lian
    Yu, Fengyun
    Wang, Pei
    Qi, Min
    [J]. JOURNAL OF APPLIED POLYMER SCIENCE, 2009, 111 (01) : 429 - 436
  • [4] Poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly (ε-caprolactone) triblock copolymers:: Synthesis and self-assembly in aqueous solutions
    Zhang, Yaqiong
    Guo, Shengrong
    Lu, Chengfei
    Liu, Li
    Li, Zonghai
    Gu, Jianren
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2007, 45 (04) : 605 - 613
  • [5] Degradation behavior of poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) micelles in aqueous solution
    Hu, Y
    Zhang, LY
    Cao, Y
    Ge, HX
    Jiang, XQ
    Yang, CZ
    [J]. BIOMACROMOLECULES, 2004, 5 (05) : 1756 - 1762
  • [6] Systhesis and micellization of poly (Ε-caprolactone)-b-poly (ethylene glycol)-b-poly (2-hydroxyethyl methacrylate) triblock copolymers
    [J]. Luo, X.-L. (luoxl_scu@126.com), 1600, Journal of Functional Materials (45):
  • [7] Nonisothermal Crystallization and Melting Behavior of Poly(ε-caprolactone)-b-Poly(ethylene glycol)-b-Poly(ε-caprolactone) by DSC Analysis
    Wei, Zhiyong
    Yu, Fengyun
    Chen, Guangyi
    Qu, Chao
    Wang, Pei
    Zhang, Wanxi
    Liang, Jicai
    Qi, Min
    Liu, Lian
    [J]. JOURNAL OF APPLIED POLYMER SCIENCE, 2009, 114 (02) : 1133 - 1140
  • [8] Synthesis and characterization of star poly(ε-caprolactone)-b-poly(ethylene glycol) and poly(L-lactide)-b-poly(ethylene glycol) copolymers:: Evaluation as drug delivery carriers
    Wang, Fei
    Bronich, Tatiana K.
    Kabanov, Alexander V.
    Rauh, R. David
    Roovers, Jacques
    [J]. BIOCONJUGATE CHEMISTRY, 2008, 19 (07) : 1423 - 1429
  • [9] Hybrid Single Crystals of Poly(ε-caprolactone) Homopolymers and Poly(ε-caprolactone)-b-Poly(ethylene oxide) Block Copolymers
    Yang, Chen
    Li, Zi-Xian
    Xu, Jun-Ting
    [J]. MACROMOLECULAR CHEMISTRY AND PHYSICS, 2024,
  • [10] Synthesis and characterization of poly(ethylene glycol)-b-poly(ε-caprolactone) copolymers with functional side groups on the polyester block
    Chen, Wen-Hsin
    Hua, Mu-Yi
    Lee, Ren-Shen
    [J]. JOURNAL OF APPLIED POLYMER SCIENCE, 2012, 125 (04) : 2902 - 2913
12345