New alkaloids from Phoebe grandis (Nees) Merr.

被引：9

作者：

Awang, Khalijah ^{[1
]}

Mukhtar, Mat Ropi

Hadi, A. Hamid A.

Litaudon, Marc

Latip, Jalifah

Abdullah, Noor Rain

机构：

[1] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[3] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Chem Sci & Food Technol, Bangi 43600, Malaysia

[4] Inst Med Res, Herbal Med Res Ctr, Inst Med Res, Kuala Lumpur 50588, Malaysia

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 06期

关键词：

proaporphine-tryptamine dimer; phoebegrandine D; phoebegrandine E; NMR; Phoebe grandis; alkaloid;

D O I：

10.1080/14786410500183944

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D ( 1), a proaporphine - tryptamine dimer, and phoebegrandine E ( 2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50 < 8 mu g mL(-1)). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS.

引用

页码：567 / 572

页数：6

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