Determination of protein subcellular localization in apicomplexan parasites

被引：11

作者：

Woodcroft, Ben J. ^{[1
,2
]}

McMillan, Paul J. ^{[1
,3
]}

Dekiwadia, Chaitali ^{[1
]}

Tilley, Leann ^{[1
,3
]}

Ralph, Stuart A. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia

[2] Walter & Eliza Hall Inst Med Res, Div Bioinformat, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Australian Res Council Ctr Excellence Coherent Xr, Parkville, Vic 3010, Australia

来源：

TRENDS IN PARASITOLOGY | 2012年 / 28卷 / 12期

基金：

澳大利亚研究理事会;

关键词：

Apicomplexa; Plasmodium; Toxoplasma; cell biology; subcellular localization; organelles; microscopy; GFP; antibody; PLASMODIUM-FALCIPARUM; TOXOPLASMA-GONDII; MALARIA PARASITE; TRANSIENT TRANSFECTION; STABLE TRANSFECTION; PROTEOMIC ANALYSIS; BABESIA-BOVIS; QUANTUM DOTS; IDENTIFICATION; ERYTHROCYTES;

D O I：

10.1016/j.pt.2012.08.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Parasites from the phylum Apicomplexa include causative agents of serious diseases including malaria (Plasmodium spp.) and toxoplasmosis (Toxoplasma gondii). Apicomplexan parasites infect thousands of types of animal cells and send their proteins to an array of compartments within their own cell, as well as exporting proteins into and beyond their host cell. Ascertaining destinations to which individual proteins are delivered allows researchers to better understand parasite biology and to identify potential targets for therapeutic interventions. Our toolkit for establishing subcellular locations of apicomplexan proteins is becoming more extensive and specialized, and here we review developments in this technology.

引用

页码：546 / 554

页数：9

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