A Survey on Synthesis Processes of Structured Materials for Biomedical Applications: Iron-based Magnetic Nanoparticles, Polymeric Materials and Polymerization Processes

被引:10
|
作者
Neto, Weslany Silverio [1 ]
Jensen, Alan Thyago [1 ]
Ferreira, Gabriella Ribeiro [1 ]
Valadares, Leonardo Fonseca [2 ]
Gambetta, Rossano [2 ]
Goncalves, Silvia Belem [2 ]
Machado, Fabricio [1 ]
机构
[1] Univ Brasilia, Inst Quim, BR-70904970 Brasilia, DF, Brazil
[2] Embrapa Agroenergia, BR-70770901 Brasilia, DF, Brazil
关键词
Iron oxides; magnetic nanoparticles; superparamagnetism; core-shell polymer particles; heterogeneous polymerization processes; embolization; drug delivery; hydrogel; UTERINE ARTERY EMBOLIZATION; CHLORIDE SUSPENSION POLYMERIZATION; TRISACRYL GELATIN MICROSPHERES; MODIFIED FE3O4 NANOPARTICLES; NEAR-INFRARED SPECTROSCOPY; POLYVINYL-ALCOHOL FOAM; DRUG-DELIVERY-SYSTEMS; OXIDE NANOPARTICLES; FERRITE NANOPARTICLES; IN-VITRO;
D O I
10.2174/1381612821666150917093031
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Magnetic materials based on iron oxides are extensively designed for several biomedical applications. Heterogeneous polymerization processes are powerful tools for the production of tailored micro-sized and nanosized magneto-polymeric particles. Although several polymerization processes have been adopted along the years, suspension, emulsion and miniemulsion systems deserve special attention due to its ability to produce spherical polymer particles containing magnetic nanoparticles homogeneously dispersed into the polymer thermoplastic matrices. The main objective of this paper is to review the main methods of synthesis of iron-based magnetic nanoparticles and to illustrate how typical polymerization processes in different dispersion medium can be successfully used to produce engineered magnetic core-shell structures. It is exemplified the use of suspension, emulsion and miniemulsion polymerization processes in order to support experimental methodologies required for the production of magnetic polymer particles intended for biomedical applications such as intravascular embolization treatments, drug delivery systems and hyperthermia treatment.
引用
收藏
页码:5336 / 5358
页数:23
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