Sarcophyolides B-E, New Cembranoids from the Soft Coral Sarcophyton elegans

被引：40
|
作者：
Xi, Zhifang [1 ]
Bie, Wei [1 ,2 ]
Chen, Wei [1 ]
Liu, Dong [1 ]
van Ofwegen, Leen [3 ]
Proksch, Peter [4 ]
Lin, Wenhan [1 ]
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Beijing Entry Exit Inspect & Quarantine Bur, Chem Anal Dept, Beijing 100026, Peoples R China
[3] Natl Museum Nat Hist, Nat Biodivers Ctr, NL-2300 Leiden, Netherlands
[4] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
来源：
MARINE DRUGS | 2013年 / 11卷 / 09期
关键词：
soft coral; Sarcophyton elegans; sarcophyolide; cembranoid; cytotoxicity; MARINE TERPENES; GLAUCUM; CRASSOCAULE; GENUS; SINULARIA;
D O I：
10.3390/md11093186
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.
引用
收藏
页码：3186 / 3196
页数：11
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