Photocrosslinked Poly(vinyl alcohol) Nanofibrous Scaffolds

Biocompatible photocrosslinked poly(vinyl alcohol) nanofibrous Scaffolds were successfully prepared by electrospinning and consequent photopolymerization. The nanofibrous membranes were subjected to detailed analysis by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). SEM images showed that morphology and diameter of the nanofibers were mainly affected by degree of substitute of metharyloyl group. XRD and DSC demonstrated form of a larger fraction of amorphous phase due to destroyed hydrogen bonding through methacrylation. Water stability test showed that the nanofibrous membranes improved its water stability with crosslinking degree increased. The indirect cytotoxicity assessments of the nanofibers were studied. And the result indicated the nanofibers was nontoxic to the L929 cells. This novel electrospun matrix would be used as potential wound dressing for skin regeneration.