Is Renal Allograft Dysfunction a Risk Factor for Severe Infection in Kidney Transplant Recipients?

被引：5
|
作者：
Mourad, G. [1 ]
Dussol, B. [2 ]
Daugas, E. [3 ]
Joly, D. [4 ]
Juillard, L. [5 ]
Henri, P. [6 ]
Stroumza, P. [7 ]
Touam, M. [8 ]
机构：
[1] Univ Montpellier, Hop Lapeyronie, Dept Nephrol & Transplantat, F-34295 Montpellier 05, France
[2] Hop Conception, Dept Nephrol & Transplantat, Marseille, France
[3] Hop Bichat Claude Bernard, Dept Nephrol, F-75877 Paris, France
[4] Hop Necker Enfants Malad, Dept Nephrol, Paris, France
[5] Hop Edouard Herriot, Dept Nephrol, Lyon, France
[6] Hop Clemenceau, Dept Nephrol, Caen, France
[7] Dialysis Ctr Diaverum, Marseille, France
[8] Dialysis Ctr AURA, Paris, France
来源：
TRANSPLANTATION PROCEEDINGS | 2012年 / 44卷 / 09期
关键词：
DEATH;
D O I：
10.1016/j.transproceed.2012.09.088
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The ANTICIPE study is a cross-sectional, multicenter, French study. The aim of this study was to describe clinical and biological parameters observed in a cohort of 1446 stable renal transplant recipients, according to the stage of chronic kidney disease. Severe infection was defined as an infection necessitating >= 7 days of hospital stay. We observed a negative correlation between declining glomerular filtration rate and occurrence of severe infection (P < .0001). In multivariate analysis, severe infection was associated with age, female gender, chronic kidney disease stage (Kidney Disease Outcomes Quality Initiative classification), and number of acute rejection episodes. Our study suggested that renal allograft function is a predictor not only of cardiac death and cardiovascular complications, but also of severe infections.
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页码：2821 / 2823
页数：3
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