Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

被引:67
|
作者
Williams, Pete A. [1 ,2 ]
Howell, Gareth R. [2 ]
Barbay, Jessica M. [2 ]
Braine, Catherine E. [2 ]
Sousa, Gregory L. [2 ]
John, Simon W. M. [2 ,3 ,4 ]
Morgan, James E. [1 ,5 ]
机构
[1] Cardiff Univ, Sch Optometry & Vis Sci, Cardiff CF10 3AX, S Glam, Wales
[2] Jackson Lab, Bar Harbor, ME 04609 USA
[3] Howard Hughes Med Inst, Bar Habor, ME USA
[4] Tufts Univ Med, Dept Ophthalmol, Boston, MA USA
[5] Univ Wales Hosp, Cardiff Eye Unit, Cardiff CF4 4XW, S Glam, Wales
来源
PLOS ONE | 2013年 / 8卷 / 08期
关键词
INTRAOCULAR-PRESSURE ELEVATION; MOUSE MODEL; RAT MODEL; DEGENERATION; DAMAGE; OPA1; APOPTOSIS; RESPONSES; NEURODEGENERATION; MITOCHONDRIA;
D O I
10.1371/journal.pone.0072282
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss. The common site of damage to retinal ganglion cells is thought to be at the optic nerve head, however evidence from other optic neuropathies and neurodegenerative disorders suggests that dendritic structures undergo a prolonged period of atrophy that may accompany or even precede soma loss and neuronal cell death. Using the DBA/2J mouse model of glaucoma this investigation aims to elucidate the impact of increasing intraocular pressure on retinal ganglion cell dendrites using DBA/2J mice that express YFP throughout the retinal ganglion cells driven by Thy1 (DBA/2J. Thy1(YFP)) and DiOlistically labelled retinal ganglion cells in DBA/2J mice. Here we show retinal ganglion cell dendritic degeneration in DiOlistically labelled DBA/2J retinal ganglion cells but not in the DBA/2J. Thy1(YFP) retinal ganglion cells suggesting that a potential downregulation of Thy1 allows only 'healthy' retinal ganglion cells to express YFP. These data may highlight alternative pathways to retinal ganglion cell loss in DBA/2J glaucoma.
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页数:10
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