Palladium-Catalyzed Three-Component Tandem Reaction for One-pot Highly Stereoselective Synthesis of (Z)-α-Hydroxymethyl Allylic Sulfones

被引：26
|
作者：
Hou, Yunlei [1 ]
Shen, Qi [1 ]
Li, Zefei [1 ]
Chen, Shaowei [1 ]
Zhao, Yanfang [1 ]
Qin, Mingze [1 ]
Gong, Ping [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 04期
关键词：
allylic sulfones; three-component tandem reaction; Pd-catalyzed; sulfonyl hydrazides; allenes; C-H AMINATION; ARYL IODIDES; ALLENYLBORONATE PLATFORM; ORGANIC-SYNTHESIS; ALLYLATION; ALLENES; HYDRAZIDES; ALCOHOLS; AMINES; SULFONYLATION;
D O I：
10.1002/adsc.201701011
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel method is reported for the stereoselective synthesis of highly functionalized allyl aryl sulfones. This protocol is based on a Pd-catalyzed three-component tandem reaction of sulfonyl hydrazides and aryl iodides with allenes and exhibits high (Z)-selectivity, good yields, minimal waste, ample product scope, and operational simplicity.
引用
收藏
页码：631 / 636
页数：6
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