Repair of cellular radiation damage in space under microgravity conditions

被引:26
|
作者
Pross, HD [1 ]
Kiefer, J [1 ]
机构
[1] Univ Giessen, Strahlenzentrum, D-35392 Giessen, Germany
关键词
D O I
10.1007/s004110050149
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they were incubated at the permissive temperature to allow repair. Before re-entry they were again cooled down and kept at a low temperature until final analysis. The experiment, which was flown on the shuttle Atlantis on flight STS-76 (SMM-03), showed that repair of preformed DNA double-strand breaks in yeast is not impaired by microgravity.
引用
收藏
页码:133 / 138
页数:6
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