Study on the crystal structure of RS-1-(2-methoxyphenyl)-4-[3-(1-naphthyloxy)-2-hydroxypropyl]-piperazine

被引：0
|
作者：
Yuan, M [1 ]
Wu, N
Zhou, JG
Lü, Y
Zheng, QT
机构：
[1] Guiyang Med Coll, Dept Pharm, Guiyang 550004, Peoples R China
[2] Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 1999年 / 18卷 / 04期
关键词：
naftopidil; crystal structure; antihypertensive;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In order to confirm the existence and the position of the hydroxy group in the RS-1-(2-methoxyphenyl)-4-[3-(1-naphthyloxy)-2-hydroxypropyl]-piperazine (C24H28N2O3) molecule, which is found to be a selective antagonist against postsynaptie membrane alpha(1) receptor, its crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to the triclinic system: and the space group is P (1) over bar, with a=7.375(2), b=11.733(2), c=12.402(2) Angstrom, alpha=91.68(2), beta=101.31 (3), gamma=95.40(2)degrees, V=1046.4(4) Angstrom(3), Z=2, D-c=1.246 g/cm(3). Final R-f=0.076.
引用
收藏
页码：315 / 316
页数：2
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