Piroxicam ex vivo release kinetics from zein/pectin delivery systems

被引：4
|
作者：
Bobokalonov, D. T. [1 ]
Mukhidinov, Z. K. [1 ]
Rakhimov, I. F. [1 ]
Khodzhaeva, F. M. [1 ]
Kasymova, G. F. [1 ]
Liu, L. S. [2 ]
机构：
[1] Tajik Acad Sci, Nikitin Inst Chem, Dushanbe 834063, Tajikistan
[2] ARS, Eastern Reg Res Ctr, USDA, Wyndmoor, PA 19038 USA
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2012年 / 46卷 / 06期
关键词：
pectin; zein; hydrogel; drug delivery system; ex vivo; piroxicam;
D O I：
10.1007/s11094-012-0803-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Piroxicam ex vivo release kinetics from zein/pectin drug delivery systems were studied using rat cecum. The piroxicam release kinetic parameters were calculated using a first-order equation and the Peppas equation. The results indicated that diffusion of the therapeutic agent was the rate-limiting step in piroxicam release from the hydrogel microspheres. The created therapeutic drug forms based on biodegradable polymers were an alternative to the peroral administration of most drugs with limited bioavailability.
引用
收藏
页码：378 / 380
页数：3
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