PECTIN-ZEIN MICROSPHERES AS DRUG DELIVERY SYSTEMS

被引：16
|
作者：
Mukhidinov, Z. K. [1 ]
Kasimova, G. F. [1 ]
Bobokalonov, D. T. [1 ]
Khalikov, D. Kh. [1 ]
Teshaev, Kh. I. [1 ]
Khalikova, M. D. [1 ]
Liu, L. -S. [2 ]
机构：
[1] Tajik Acad Sci, Inst Chem, Dushanbe, Tajikistan
[2] USDA, Eastern Reg Res Ctr, Philadelphia, PA 19118 USA
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 44卷 / 10期
关键词：
pectin; zein; microspheres; drug delivery systems;
D O I：
10.1007/s11094-011-0518-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The formation of microspheres from various pectin hydrogel complexes and corn zein in the presence of calcium and zinc ions has been studied. It is shown that the formation of microspheres and their loading capacity for a drug (piroxicam) depend on the type of biopolymers, their ratio, the sizes of the bivalent ions, and the molecular mass of the pectin. Complex formation between the two biopolymers results predominantly from bivalent metal cross-linking for low-methylated pectins and from hydrophobic interaction for high-methylated pectins. As a result, a series of microspheres have been prepared from biodegradable and biocompatible polymers and may find application as controlled-release drug delivery systems.
引用
收藏
页码：564 / 567
页数：4
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