The structural immunology of antibody protection against West Nile virus

被引：96
|
作者：
Diamond, Michael S. [1 ,2 ,3 ]
Pierson, Theodore C. [5 ]
Fremont, Daved H. [3 ,4 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA
[5] NIH, Viral Pathogenesis Sect, Viral Dis Lab, Bethesda, MD 20892 USA
来源：
IMMUNOLOGICAL REVIEWS | 2008年 / 225卷
关键词：
infectious diseases; antibodies; emerging infectious disease; antigens/peptides/epitopes; complement;
D O I：
10.1111/j.1600-065X.2008.00676.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent investigations of the interaction between the West Nile virus (WNV) envelope protein (E) and monoclonal antibodies (mAbs) have elucidated fundamental insights into the molecular mechanisms of neutralization. Structural studies have defined an epitope on the lateral ridge of domain III (DIII-lr) of the WNV E protein that is recognized by antibodies with the strongest neutralizing activity in vitro and in vivo. Antibodies that bind this epitope are highly potent because they efficiently block at a post-entry step of viral infection with relatively low virion occupancy requirements. In this review, we discuss the structural, molecular, and immunologic basis for antibody-mediated protection against WNV, and its implications for novel therapeutic or vaccine strategies.
引用
收藏
页码：212 / 225
页数：14
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