Synthesis of quinazolines from 2-aminobenzylamines with benzylamines and N-substituted benzylamines under transition metal-free conditions

被引：22

作者：

Tiwari, Abhishek R. ^{[1
]}

Bhanage, Bhalchandra M. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Chem, Mumbai, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 45期

关键词：

2-SUBSTITUTED QUINAZOLINES; TANDEM CYCLIZATION; FUNCTIONALIZATION; INHIBITORS; ARYLATION; CATALYST; ACIDS;

D O I：

10.1039/c6ob02163h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work reports the synthesis of quinazolines from 2-aminobenzylamines with N-substituted benzylamines in the presence of molecular iodine. The developed methodology works smoothly under transition-metal free, additive free and solvent free conditions. The use of O-2 as a green oxidant makes it a greatly economical, green and sustainable protocol. Moreover, no aqueous work up is required thereby enhancing the efficiency. A series of quinazoline derivatives were synthesized successfully in good to excellent yields.

引用

页码：10567 / 10571

页数：5

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