Synthetic studies toward the total synthesis of tedanolide: assembly of the C1-C23 carbon backbone

被引:16
|
作者
Wong, Chek-Ming [1 ]
Loh, Teck-Peng [1 ]
机构
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 639716, Singapore
关键词
tedanolide; stereoselective; aldol; boron reagent; fragment assembly;
D O I
10.1016/j.tetlet.2006.04.044
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A stereoselective assembly of the C1-C23 fragment representing the carbon backbone of tedanolide was accomplished utilizing a chiral boron reagent to effect the aldol coupling of the C1-C12 diketoester fragment with the C13-C23 aldehyde fragment. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4485 / 4489
页数:5
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