Personalized Medicine in Respiratory Disease: Role of Proteomics

被引:16
|
作者
Priyadharshini, V. S. [1 ]
Teran, Luis M. [1 ]
机构
[1] Delegac Tlalpan, Inst Nacl Enfemedades Resp, Mexico City, DF, Mexico
关键词
CELL LUNG-CANCER; IDIOPATHIC PULMONARY-FIBROSIS; BRONCHOALVEOLAR LAVAGE FLUID; TYROSINE KINASE INHIBITORS; CYSTIC-FIBROSIS; MASS-SPECTROMETRY; GEL-ELECTROPHORESIS; CFTR POTENTIATOR; CONFORMATIONAL MATURATION; QUANTITATIVE PROTEOMICS;
D O I
10.1016/bs.apcsb.2015.11.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Respiratory diseases affect humanity globally, with chronic lung diseases (e.g., asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, among others) and lung cancer causing extensive morbidity and mortality. These conditions are highly heterogeneous and require an early diagnosis. However, initial symptoms are non-specific, and the clinical diagnosis is made late frequently. Over the last few years, personalized medicine has emerged as a medical care approach that uses novel technology aiming to personalize treatments according to the particular patient's medical needs. This review highlights the contributions of proteomics toward the understanding of personalized medicine in respiratory disease and its potential applications in the clinic.
引用
收藏
页码:115 / 146
页数:32
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