Sustained release of BSA from a novel drug delivery matrix-bullfrog skin collagen film

被引：14
|
作者：
Li, H
Wang, DQ
Li, SJ
Liu, BL
Gao, LZ
机构：
[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Sch Optoelect Informat, Chengdu 610054, Sichuan, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2004年 / 4卷 / 04期
关键词：
bovine serum albumin (BSA); bullfrog skin collagen; drug delivery systems;
D O I：
10.1002/mabi.200300039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel drug delivery system, bullfrog skin collagen film, was employed to release bovine serum albumin (BSA). The biophysical properties of bullfrog skin collagen film used were evaluated by thermal denaturation temperature and percentage water loss. The film obtained exhibited good stability and can be taken as a good candidate for drug delivery matrix. Compared with conventional collagen from molecular weight and amino acid composition, bullfrog skin collagen showed significant differences. For safety considerations, bullfrog skin collagen has great advantages. The release kinetics of BSA from bullfrog skin collagen film was measured in vitro. The results indicated bullfrog skin collagen film could be used for sustained release of BSA. Thus, bullfrog skin collagen film can be taken as a novel drug delivery system.
引用
收藏
页码：454 / 457
页数：4
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