Development of a new environmentally friendly production process for terbinafine

被引：0
|
作者：
Beutler, U [1 ]
Mazacek, J [1 ]
Penn, G [1 ]
Schenkel, B [1 ]
Wasmuth, D [1 ]
机构：
[1] SANDOZ PHARMA AG,CH-4002 BASEL,SWITZERLAND
来源：
CHIMIA | 1996年 / 50卷 / 04期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient process for the production of terbinafine is described. Starting from (E)-1,3-dichloropropene, neohexene, and N-methyl-(1-naphthylmethyl)amine and using a palladium-catalyzed coupling methodology, terbinafine is produced exclusively as (E)-isomer in a convergent manner. The new process avoids the very toxic and nasty starting materials acrolein and phosphorus pentachloride used in the old process.
引用
收藏
页码：154 / 156
页数：3
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