Development of a new environmentally friendly production process for terbinafine

被引：0

作者：

Beutler, U ^{[1
]}

Mazacek, J ^{[1
]}

Penn, G ^{[1
]}

Schenkel, B ^{[1
]}

Wasmuth, D ^{[1
]}

机构：

[1] SANDOZ PHARMA AG,CH-4002 BASEL,SWITZERLAND

来源：

CHIMIA | 1996年 / 50卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient process for the production of terbinafine is described. Starting from (E)-1,3-dichloropropene, neohexene, and N-methyl-(1-naphthylmethyl)amine and using a palladium-catalyzed coupling methodology, terbinafine is produced exclusively as (E)-isomer in a convergent manner. The new process avoids the very toxic and nasty starting materials acrolein and phosphorus pentachloride used in the old process.

引用

页码：154 / 156

页数：3

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