Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release

被引：36

作者：

Ozkahraman, Bengi ^{[1
]}

Tamahkar, Emel ^{[2
,3
]}

Idil, Neslihan ^{[4
]}

Kilic Suloglu, Aysun ^{[4
]}

Percin, Isik ^{[4
]}

机构：

[1] Hitit Univ, Dept Polymer Engn, Corum, Turkey

[2] Hitit Univ, Dept Chem Engn, Corum, Turkey

[3] Balikesir Univ, Dept Food Engn, Balikesir, Turkey

[4] Hacettepe Univ, Dept Biol, Ankara, Turkey

来源：

DRUG DEVELOPMENT RESEARCH | 2021年 / 82卷 / 02期

关键词：

antibiotic release; chitosan-gelatin hydrogels; hyaluronic acid nanoparticles embedding; DRUG-RELEASE; DELIVERY; FILMS; SCAFFOLDS;

D O I：

10.1002/ddr.21747

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.

引用

页码：241 / 250

页数：10

共 50 条

[31] Release of Plasmid DNA from Nano-Hydroxyapatite/Chitosan-Gelatin Composite Scaffolds
Liu Jinsong
Zhang Hualin
Wang Qi
Yang Jun
Gao Ning
Chen Zhiqing
RARE METAL MATERIALS AND ENGINEERING, 2009, 38 : 850 - 853
[32] Synthesis of hydroxyapatite nanoparticle and role of its size in hydroxyapatite/chitosan-gelatin biocomposite for bone grafting
Mohonta, Sajib Kumar
Maria, Kazi Hanium
Rahman, Sharmin
Das, Harinarayan
Hoque, Sheikh Manjura
INTERNATIONAL NANO LETTERS, 2021, 11 (04) : 381 - 393
[33] Tailoring solubility and drug release from electrophoretic deposited chitosan-gelatin films on titanium
Patel, Kapil D.
Singh, Rajendra K.
Lee, Eun-Jung
Han, Cheol-Min
Won, Jong-Eun
Knowles, Jonathan C.
Kim, Hae-Won
SURFACE & COATINGS TECHNOLOGY, 2014, 242 : 232 - 236
[34] Evaluation of the Effect of Honey-Containing Chitosan/Hyaluronic Acid Hydrogels on Wound Healing
Salva, Emine
Akdag, Ahmet Enes
Alan, Saadet
Arisoy, Sema
Akbuga, Fatma Julide
GELS, 2023, 9 (11)
[35] Influence of the acid type on the physical and drug liberation properties of chitosan-gelatin sponges
Leffler, CC
Müller, BW
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 194 (02) : 229 - 237
[36] Preparation and bioactivity evaluation of hydroxyapatite-titania/chitosan-gelatin polymeric biocomposites
Mohamed, Khaled R.
Mostafa, Amam A.
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2008, 28 (07): : 1087 - 1099
[37] Fabrication and evaluation of chitosan-gelatin based buckling implant for retinal detachment surgery
Chen, Hui
Zhao, Zhi
Zhao, Yahong
Yang, Yumin
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (10) : 2887 - 2895
[38] Fabrication and Biocompatibility of Chitosan/Gelatin/Hyaluronic Acid/MWCNTs Scaffolds
Stem Cell and Tissue Engineering Laboratory, Dalian University of Technology, Dalian
116024, China
Gao Xiao Hua Xue Gong Cheng Xue Bao, 5 (1143-1149):
[39] In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery
Song, Yuanhui
Nagai, Nobuhiro
Saijo, Saaya
Kaji, Hirokazu
Nishizawa, Matsuhiko
Abe, Toshiaki
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2018, 88 : 1 - 12
[40] Preparation and characterization of injectable chitosan-hyaluronic acid hydrogels for nerve growth factor sustained release
Xu, Haixing
Zhang, Lingxi
Bao, Yun
Yan, Xiumei
Yin, Yixia
Li, Yiping
Wang, Xinyu
Huang, Zhijun
Xu, Peihu
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2017, 32 (02) : 146 - 162

← 1 2 3 4 5 →