Effect of MUC8 on Airway Inflammation: A Friend or a Foe?

被引：7

作者：

Cha, Hee-Jae ^{[1
]}

Song, Kyoung Seob ^{[2
]}

机构：

[1] Kosin Univ, Coll Med, Dept Parasitol & Genet, 34 Amnam Dong, Busan 49267, South Korea

[2] Kosin Univ, Dept Physiol, Coll Med, 34 Amnam Dong, Busan 49267, South Korea

来源：

JOURNAL OF CLINICAL MEDICINE | 2018年 / 7卷 / 02期

关键词：

MUC8; airway inflammation; inflammatory cytokines; mucus hypersecretion/overproduction; negative regulator; ACTIVATED PROTEIN-KINASE; ELEMENT-BINDING PROTEIN; EPITHELIAL-CELLS; GENE-EXPRESSION; P38; MAPK; UP-REGULATION; MUC5AC; HYPERSECRETION; ORGANIZATION; SECRETION;

D O I：

10.3390/jcm7020026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, we compile identifying molecular mechanisms of MUC8 gene expression and studies characterizing the physiological functions of MUC8 in the airway and analyzing how altered MUC8 gene expression in the lung is affected by negative regulators.

引用

页数：5

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