Turnover of T cells in murine gammaherpesvirus 68-infected mice

被引:13
|
作者
Hamilton-Easton, AM [1 ]
Christensen, JP [1 ]
Doherty, PC [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
关键词
D O I
10.1128/JVI.73.9.7866-7869.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Respiratory challenge of C57BL/6 mice with murine gammaherpesvirus 68 induces proliferation of T lymphocytes early after infection, as evidenced by incorporation of the DNA precursor bromodeoxyuridine. Using pulse-chase analysis, splenic and peripheral blood activated T lymphocytes were found to continue dividing for at least a month after the initial virus challenge. The results are in accord with the idea that T cells are stimulated for a substantial time after the acute, lytic phase of virus infection is resolved.
引用
收藏
页码:7866 / 7869
页数:4
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