Turnover of T cells in murine gammaherpesvirus 68-infected mice

被引：13

作者：

Hamilton-Easton, AM ^{[1
]}

Christensen, JP ^{[1
]}

Doherty, PC ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 09期

关键词：

D O I：

10.1128/JVI.73.9.7866-7869.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Respiratory challenge of C57BL/6 mice with murine gammaherpesvirus 68 induces proliferation of T lymphocytes early after infection, as evidenced by incorporation of the DNA precursor bromodeoxyuridine. Using pulse-chase analysis, splenic and peripheral blood activated T lymphocytes were found to continue dividing for at least a month after the initial virus challenge. The results are in accord with the idea that T cells are stimulated for a substantial time after the acute, lytic phase of virus infection is resolved.

引用

页码：7866 / 7869

页数：4

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