The nucleophilic ring-opening of N-benzylquinuclidinium bromide

被引：10
|
作者：
Axelsson, O
Peters, D
机构：
[1] NeuroSearch A/S, DK-2600 Glostrup
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 02期
关键词：
D O I：
10.1002/jhet.5570340217
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Benzylquinuclidinium bromide was ring opened by a series of heteronucleophiles, in the presence of cesium carbonate, to yield the corresponding N-benzyl-4-(2-hetero-ethyl)piperidines. The best yields were found with thiophenol (56%), phenol (55%), and benzimidazole (38%) as nucleophiles.
引用
收藏
页码：461 / 463
页数：3
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