Fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 to anhydrides: synthesis of γ-difluoromethylated γ-lactams

被引：28
|
作者：
Pharikronburee, Vannapha
Punirun, Teerachai
Soorukram, Darunee
Kuhakarn, Chutima
Tuchinda, Patoomratana
Reutrakul, Vichai
Pohmakotr, Manat [1 ]
机构：
[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 12期
关键词：
OXIDATIVE TRIFLUOROMETHYLATION; ELECTROPHILIC FLUORINATION; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC FLUORINATION; ARYL; CYCLIZATION; STRATEGY; ACIDS; ME3SICF2SPH; SULFOXIDES;
D O I：
10.1039/c3ob27193e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
PhSCF2SiMe3 (1) underwent fluoride-catalyzed nucleophilic addition to the carbonyl group of anhydrides to provide the corresponding gamma-difluoro(phenylsulfanyl) methyl gamma-lactols, which were employed for the synthesis of gamma-difluoromethylated gamma-lactams.
引用
收藏
页码：2022 / 2033
页数：12
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