Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT2 receptors

被引：12
|
作者：
Lee, K [1 ]
Dixon, AK [1 ]
Pinnock, RD [1 ]
机构：
[1] Univ Cambridge, Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England
来源：
NEUROSCIENCE LETTERS | 1999年 / 270卷 / 01期
关键词：
whole-cell patch clamp; serotonin; hippocampus;
D O I：
10.1016/S0304-3940(99)00449-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Patch-clamp recording techniques were used to examine the effect of serotonin (5HT) upon interneurones contained in the stratum oriens layer of hippocampal slices. Bath application of 1-20 mu M 5HT depolarized neurones by the induction of an inward current at -60 mV. This inward current was Na+-dependent in nature, was mimicked by the 5HT(2) receptor agonist 1 -(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and was inhibited by pre-incubation with the 5HT2 receptor antagonist ritanserin. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：56 / 58
页数：3
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