Inheritance of L1014F and M918T sodium channel mutations associated with pyrethroid resistance in Myzus persicae

被引：10
|
作者：
Eleftherianos, Ioannis [1 ]
Foster, Stephen P. [1 ]
Williamson, Martin S. [1 ]
Denholm, Ian [1 ]
机构：
[1] Rothamsted Res, Harpenden AL5 2JQ, Herts, England
来源：
BIOLOGY LETTERS | 2008年 / 4卷 / 05期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Myzus persicae; knock-down resistance; sodium channel; pyrethroids; inheritance; dominance;
D O I：
10.1098/rsbl.2008.0225
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two amino acid substitutions (L1014F and M918T) in the voltage-gated sodium channel confer target-site resistance to pyrethroid insecticides in the peach potato aphid, Myzus persicae. Pyrethroid-resistant and -susceptible M. persicae clones with various combinations of these mutations were crossed under laboratory conditions, and the genotypes of aphid progeny were analysed by direct DNA sequencing of the IIS4-S6 region of the sodium channel gene. Segregation patterns showed that in aphids heterozygous for both L1014F and M918T, both mutations were present in the same resistance allele. Despite these mutations appearing largely recessive in other pest species, such aphids exhibited strong resistance to pyrethroids in leaf-dip bioassays. These results have important implications for the spread and management of pyrethroid resistance in field populations.
引用
收藏
页码：545 / 548
页数：4
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